Novel Ketogenic Ester Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults March 25, 2022 The Ketone Di-ester in Metabolic Switch is proven to effectively induce ketosis in healthy adults.
Incidence, Persistence, and Remission Rates of Insomnia Over 5 Years November 06, 2020 Insomnia. How prevalent? How serious? This study examines the disorder over a five year period and offers insights into a condition that impacts current health and longevity.
Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure September 11, 2020 Human liver disease is modeled in swine. Liver cells transplanted, forming ectopic livers that cured fatal disease.
Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes August 18, 2020 Transplanted swine liver cells are engrafted into the lymph nodes, proliferated, and form ectopic mini-livers.
β-hydroxybutyrate and its Metabolic Effects on Age-associated Pathology April 07, 2020 Aging is a universal and irreversible process that renders individuals vulnerable to many diseases. Increased β-HB has been reported to prevent or improve symptoms of various age-associated diseases.
Engineering strategies for generating hypoimmunogenic cells with high clinical and commercial value October 29, 2019 The engineering of allogeneic cells to be ‘hypoimmunogenic’, also referred to as ‘universal’, so that they evade a host's immune system would be transformative for regenerative medicine.
Deep learning enables rapid identification of potent DDR1 kinase inhibitors September 01, 2019 Development of a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design, optimizes synthetic feasibility, novelty, and biological activity.
On the Metabolism of Exogenous Ketones in Humans August 27, 2019 Traditionally, ketosis has been achieved by following a “ketogenic” diet, but an alternative way to increase blood D-β-hydroxybutyrate (D-βHB) concentrations is ketone drinks, which effectively raise blood ketone concentrations.
Toward a unified theory of aging and regeneration August 27, 2019 A unified model of aging and loss of regenerative potential is emerging that may ultimately be translated into new therapeutic approaches for establishing induced tissue regeneration and modulation of the...
Host Lymphotoxin-β Receptor Signaling Is Crucial for Angiogenesis of Metanephric Tissue Transplanted into Lymphoid Sites August 18, 2019 Unraveling some of the molecular signaling that appears to be crucial for engrafted kidney tissue to grow.
Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates July 02, 2019 Expands upon findings in mice that show human ectopic kidney tissues can be grown using the lymph node as a bioreactor.
Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells January 07, 2019 Exploration of an alternative approach involving the identification of clonal self-renewing human embryonic progenitor (hEP) cell lines following partial hPS cell differentiation and selection of scalable clones.
