Published Scientific Papers

  Growing interest in the metabolic state of ketosis has driven development of exogenous ketone products to induce ketosis without dietary changes. BH-BD was recently developed as Metabolic Switch®, a food...

The Ketone Di-ester in Metabolic Switch® is proven to effectively induce ketosis in healthy adults.

Human liver disease is modeled in swine. Liver cells transplanted, forming ectopic livers that cured fatal disease.

Transplanted swine liver cells are engrafted into the lymph nodes, proliferated, and form ectopic mini-livers.

The engineering of allogeneic cells to be ‘hypoimmunogenic’, also referred to as ‘universal’, so that they evade a host's immune system would be transformative for regenerative medicine.

Traditionally, ketosis has been achieved by following a “ketogenic” diet, but an alternative way to increase blood D-β-hydroxybutyrate (D-βHB) concentrations is ketone drinks, which effectively raise blood ketone concentrations.

A unified model of aging and loss of regenerative potential is emerging that may ultimately be translated into new therapeutic approaches for establishing induced tissue regeneration and modulation of the...

Unraveling some of the molecular signaling that appears to be crucial for engrafted kidney tissue to grow.

Expands upon findings in mice that show human ectopic kidney tissues can be grown using the lymph node as a bioreactor.

Exploration of an alternative approach involving the identification of clonal self-renewing human embryonic progenitor (hEP) cell lines following partial hPS cell differentiation and selection of scalable clones.

The ketones D-β-hydroxybutyrate (D-βHB) and acetoacetate are elevated during prolonged fast.

Ketogenic diets (KD) may have similar metabolic effects to dietary caloric restriction. A cyclic KD improves midlife survival and memory performance in aging mice, without affecting maximal lifespan.