β-hydroxybutyrate and its Metabolic Effects on Age-associated Pathology

Worldwide, the number of individuals aged 65 and over is increasing due to revolutions in life expectancy; yet the prevalence of age-associated diseases such as cardiovascular disease (CVD), cancers, dementia, diabetes, and Alzheimer’s disease are rising, placing a strain on global health and economic prosperity.


Modern therapies including fasting, calorie restriction, and ketogenic diets increase healthspan and lifespan in animal models, and accumulating evidence suggests that the benefits of these regimens are mediated through upregulation of the ketone body Beta-Hydroxybutyrate, (β-HB). β-HB has several molecular actions in the body that delay senescence including histone modification, suppression of the NLRP3 inflammasome, and regulation of membrane-bound G-protein coupled receptor (GPCR) and other cytoplasmic and nuclear proteins.


Elevating blood levels of β-HB using exogenous ketone esters is a promising and safe therapeutic strategy to improve healthspan and prolong lifespan.

View the full peer-reviewed scientific paper here at Nature.com.